Portobello Road in Notting Hill is home to one of London’s most popular street markets, the Portobello Road Market. The street is in the Royal Borough of Kensington and Chelsea and is almost parallel with Ladbroke Grove. The Portobello Film Festival is held at locations around Portobello Road.

In the 1740s, Portobello Farm was established, which got its name from a war victory in which the Spanish-ruled town of Puerto Bello was captured (now located in Panama). The Portobello farming area covered the land which is now St. Charles Hospital, and what had previously been known as Green’s Lane became Portobello Road.

The shops and markets of the Portobello Road of the Victorian era largely served the wealthy inhabitants of the neighborhoods that were developed around it over the years, with the working class population finding employment as construction workers, domestic servants, coachmen, messengers, and tradesmen.

The range of communities surrounding Portobello Road contributes to its cosmopolitan and energetic atmosphere, as do the many restaurants and pubs. Architecture also plays a part, as the road gracefully curves along most of its length, unlike the more formally planned layout of most of the nearby area. Dominating the area and squeezed into every available space are mid- to late-Victorian terrace houses and shops. Portobello Road is also home to the Grade II Electric Cinema, one of Britain's oldest movie theatres.

George Orwell lived in Portobello Road in the winter of 1927, and it is the setting for Paulo Coelho's 2007 novel, The Witch of Portobello. In 2008, Ruth Rendell published a novel set in the area entitled, Portobello.